|
KMID : 1140120120170020151
|
|
Cancer Prevention Research
2012 Volume.17 No. 2 p.151 ~ p.156
|
|
|
Possible Usage of Polyphenolic Compounds from Green Tea as Anticancer Supplement Agents
|
|
Lee Ji-Hwan
Lee Woo-Jung
Lee Seung-Yong
Yamabe Noriko
Kim Su-Nam
Cho Eun-Ju
Kim Hyun-Young
Kang Ki-Sung
|
|
|
Abstract
|
|
|
|
In the present study, in vitro beneficial effects of tea catechins on gastrointestinal cancer as well as nephrotoxicity were explored. Antioxidant activities of 6 green tea catechins were evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity test. To evaluate the anticancer effect, the effect of (－)-epigallocatechin-3-gallate (EGCG) as a representative tea catechin was investigated in HCT-116 human colorectal cancer and AGS human gastric cancer cells. Protective effect of EGCG against oxidative renal cell damage was measured using radical generator, 2,2’-azobis (2-amidinopropane) dihydrochloride in LLC-PK1 cells. EGCG showed the strongest DPPH radical scavenging activity and completely decreased the gastrointestinal cancer cell viability at 10 μM. Moreover, EGCG protected renal epithelial LLC-PK1 cells from oxidative damage in the dose-dependent manner. Therefore, EGCG has beneficial effects on cancer therapy by its anticancer effect and by reducing oxidative stress-induced nephrotoxicity.
|
|
|
KEYWORD
|
|
|
Tea catechin, Nephrotoxicity, Oxidative stress, Anticancer effect
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|